tandem bites is expressed by transfected mammalian cells with four tandem variable regions connected by flexible peptides. One of its paratopes targets certain tumor-associated cell surface antigen, while the other binds CD3 so as to recruit T cells. Without Fc region, its samller size (~55 kDa) gives BiTE a short serum half-life, however, it also ensures a closer proximity to the surface of both T cell and target cell. BiTEs have more than thousands of times of efficiency in lysing tumor cell compared with other CD3-bispecific or IgG antibodies. Even with a concentration as low as 10 pg/ml in cell culture, BiTEs are still able to direct multiple rounds of target cell lysis by T cells with a low effector cell : target cell ratio. All of these properties have made it one of the most important T cell recruiters for cancer treatment and immune regulation.
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